The answer depends on where you live, and whether you want to carry your gun in a concealed manner or openly, loaded or unloaded.
To carry a concealed gun, most states require a concealed carry permit. However, even with a permit, additional laws usually apply to guns in vehicles.
To learn more about concealed carry and permit requirements in your state, see Gun Control Laws, and click the link to your state under the section entitled, “Gun Laws by State”.
Some states allow you to carry a concealed gun in your car if you are a citizen of that state and you hold a concealed carry permit, but usually with certain restrictions.
In contrast to DC and California, some states like Wyoming allow open and concealed carrying of loaded guns in your vehicle, without a license. However, most states fall somewhere between DC and Wyoming, allowing open carrying in vehicles, but no legal means to transport a loaded gun. (Exceptions exist for law enforcement officers and certain security guards.)
Getting Legal Advice
Before you carry a gun in your car, be sure to research the laws that apply in your state. If you are unsure or have questions about your state's laws, or have been charged with a crime involving a firearm, seek the advice of a qualified attorney in your area.